Reporter brief
A Nutritional and Pharmacological Intervention for Body, Brain, and Longevity Effects (NIBBLE) - A Randomized Open-label Intervention of the Fasting-mimicking Diet (FMD) and Rapamycin (NIBBLE)
What happened
Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- The open-label design (participants knew their group assignment) limits evidence for efficacy, as expectations could influence self-reported outcomes
- No effect sizes or efficacy data are reported, so the magnitude of any benefit or harm is unknown
- Results in APOE4 carriers may not generalize to the broader population, and no long-term outcomes beyond 8 weeks are assessed
Study design and sample
Rct; Human.
Middle-aged adults at elevated risk for Alzheimer's disease due to the apolipoprotein (APOE) ε4 allele
- Design
- Rct
- Sample
- —
- Journal
- Cedars-Sinai Medical Center
- Published
- Sep 16, 2026
Effect size
Not recorded.
Caveats
- Assessment: Unassessed.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
Not recorded.
Previous evidence
See the Intermittent fasting timeline and recorded assessment for prior evidence.
Primary source
Cancel Death charts and briefs may be reproduced editorially with attribution to CancelDeath.com. This brief is generated from the primary recorded source facts and assessment. Its review status is shown below; verify quotations against the paper before publication.