Reporter brief

A meta-analysis of 14 randomized controlled trials (n=893, ages 30-94) examined the effect of exercise training on circulating α-Klotho. Chronic training (≥12 weeks) produced a pooled effect of Hedges' g=1.20 (95% CI 0.85-1.55). In chronic kidney disease patients specifically, exercise increased Klotho by 158.82 pg/mL and reduced FGF23 by 102.07 pg/mL. Resistance training and high-intensity interval training showed the most robust effects.

Assessment pending; this report does not establish a change in evidence.

• —Limitations have not been recorded; consult the primary source.

Meta analysis; Human.

14 RCTs with total n=893; age range 30-94 years. Emphasis on older adults (≥60 years), patients with chronic kidney disease (CKD), diabetes, and sarcopenia. Pre-frail older adults subgroup: n=69, mean age 77 years

Design

Meta analysis

Sample

893

Journal

Frontiers in Sports and Active Living</journal> <parameter name="fundingSummary">Not reported

Published

Sep 3, 2026

Pooled effect of chronic training (≥12 weeks) on s-Klotho: Hedges' g = 1.20 (95% CI 0.85-1.55). In CKD patients: MD = 158.82 pg/mL (95% CI 122.33-194.31) for Klotho; MD = -102.07 pg/mL (95% CI -176.23 to -27.91) for FGF23. In pre-frail older adults (n=69, mean age 77 years), 12-week classical resistance training significantly increased s-Klotho

• —Assessment: Superseded.
• —Only the source material recorded on this evidence page was assessed.

Not reported in abstract. · Not reported

See the Exercise timeline and recorded assessment for prior evidence.