Reporter brief
Higher epigenetic aging clocks associated with periodontitis in adults aged 50+.
What happened
This observational study of 1,559 adults aged 50 and older from NHANES (1999-2002) examined the relationship between DNA methylation-based aging clocks and periodontitis using logistic regression. Higher quartiles of PhenoAge and GrimAge2 clocks, and their acceleration measures, were associated with increased odds of periodontitis (odds ratios ranging from 1.96 to 2.80). GrimAge2 showed the highest discriminative ability with an AUC of 0.700.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- Limitations have not been recorded; consult the primary source.
Study design and sample
Cohort; Human.
Adults aged ≥50 years from the NHANES database (1999-2002)
- Design
- Cohort
- Sample
- 1,559
- Journal
- Epigenomics
- Published
- Sep 1, 2026
Effect size
PhenoAge (ORquartile4vs1 = 2.507, 95% CI: 1.181-5.324); GrimAge2 (ORquartile4vs1 = 2.796, 95% CI: 1.093-7.154); PhenoAgeAccel (ORquartile4vs1 = 1.958, 95% CI: 1.039-3.689); GrimAge2Accel (ORquartile4vs1 = 2.667, 95% CI: 1.238-5.748); GrimAge2 AUC = 0.700
Caveats
- Assessment: Superseded.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
Not recorded.
Previous evidence
See the Epigenetic clocks timeline and recorded assessment for prior evidence.
Primary source
Cancel Death charts and briefs may be reproduced editorially with attribution to CancelDeath.com. This brief is generated from the primary recorded source facts and assessment. Its review status is shown below; verify quotations against the paper before publication.