Reporter brief
Metformin and azithromycin lower acquisition costs than amoxicillin-metronidazole for periodontitis: cost analysis
What happened
This observational cost comparison analysed 445 antibiotic prescriptions for periodontitis at a UK dental hospital between 2021-2024. Azithromycin reduced acquisition costs by 55% compared to guideline-recommended amoxicillin plus metronidazole (£2.81 per course). Non-antimicrobial adjuncts including metformin 500 mg achieved up to 91% cost reductions depending on treatment duration.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- Limitations have not been recorded; consult the primary source.
Study design and sample
Observational; Human.
Antibiotic prescriptions issued at Charles Clifford Dental Hospital for periodontitis treatment
- Design
- Observational
- Sample
- 643
- Journal
- British Dental Journal
- Published
- Sep 18, 2026
Effect size
Azithromycin: 55.16% cost reduction compared to A+M; Metformin 500 mg: up to 91.46% cost reduction
Caveats
- Assessment: Pending.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
Not recorded.
Previous evidence
See the Metformin timeline and recorded assessment for prior evidence.
Primary source
Cancel Death charts and briefs may be reproduced editorially with attribution to CancelDeath.com. This brief is generated from the primary recorded source facts and assessment. Its review status is shown below; verify quotations against the paper before publication.