Reporter brief
Metformin treatment examined for effects on aging-related gene expression in older adults with impaired glucose tolerance (pilot RCT).
What happened
This pilot randomized controlled trial investigated whether metformin treatment could restore gene expression patterns in older adults with impaired glucose tolerance to match those of younger healthy subjects. The study was motivated by preclinical evidence suggesting metformin may influence cellular aging processes beyond glucose control. No sample size, treatment duration, results, or effect sizes were reported in the available abstract.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- Limitations have not been recorded; consult the primary source.
Study design and sample
Rct; Human.
Older adults with impaired glucose tolerance (IGT), compared to young healthy subjects
- Design
- Rct
- Sample
- —
- Journal
- Albert Einstein College of Medicine
- Published
- May 21, 2021
Effect size
Not recorded.
Caveats
- Assessment: Superseded.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
Not recorded.
Previous evidence
See the Metformin timeline and recorded assessment for prior evidence.
Primary source
Cancel Death charts and briefs may be reproduced editorially with attribution to CancelDeath.com. This brief is generated from the primary recorded source facts and assessment. Its review status is shown below; verify quotations against the paper before publication.