Reporter brief
Phase 2 RCT of intravitreal sirolimus versus anti-VEGF for wet AMD with prior treatment failure
What happened
This Phase 2 randomized controlled trial compared intravitreal sirolimus injections to anti-VEGF treatment in patients with wet age-related macular degeneration who had persistent retinal edema despite previous anti-VEGF therapy. The study was conducted at a single site with subject masking. Specific efficacy and safety results were not reported in the abstract provided.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- Limitations have not been recorded; consult the primary source.
Study design and sample
Rct; Human.
Subjects with wet Age-Related Macular Degeneration (wet AMD) with persistent intraretinal or subretinal edema due to neovascular AMD despite previous AntiVEGF treatment
- Design
- Rct
- Sample
- —
- Journal
- Maturi, Raj K., M.D., P.C.
- Published
- Jun 22, 2017
Effect size
Not recorded.
Caveats
- Assessment: Superseded.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
Not recorded.
Previous evidence
See the Rapamycin timeline and recorded assessment for prior evidence.
Primary source
Cancel Death charts and briefs may be reproduced editorially with attribution to CancelDeath.com. This brief is generated from the primary recorded source facts and assessment. Its review status is shown below; verify quotations against the paper before publication.