Reporter brief

This prospective cohort study of 89,010 UK Biobank participants with wearable accelerometer data found that prolonged sedentary time (≥10 hours/day) with infrequent breaks (<12 bouts/day) was associated with a 51.5% higher risk of all-cause mortality, 55.3% higher cardiovascular mortality risk, and 10% higher CVD incidence risk compared to the least sedentary group, during 8 years of follow-up. At age 50, this sedentary pattern was associated with loss of 2.8 years in men and 3.1 years in women of CVD-free life expectancy. More frequent interruptions to sedentary time attenuated these risks.

Assessment pending; this report does not establish a change in evidence.

• —Limitations have not been recorded; consult the primary source.

Cohort; Human.

UK Biobank participants (median age 63.5 years, 56.5% women) who provided 3 to 7 valid days of wrist accelerometer data

Design

Cohort

Sample

89,010

Journal

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

Published

Jul 28, 2026

Prolonged sedentary time (≥10 h/d) with low fragmentation (sedentary breaks <12 bouts/d) versus least sedentary group: all-cause mortality HR=1.515 (95% CI 1.380–1.663; 51.5% increased risk); cardiovascular mortality subdistribution HR=1.553 (95% CI 1.325–1.820; 55.3% increased risk); incident CVD HR=1.100 (95% CI 1.030–1.174; 10.0% increased risk). CVD-free life expectancy loss at age 50: men −2.770 years (95% CI −3.392 to −2.148); women −3.113 years (95% CI −3.794 to −2.432)

• —Assessment: Pending.
• —Only the source material recorded on this evidence page was assessed.

Not recorded.

See the Exercise timeline and recorded assessment for prior evidence.