Reporter brief
RCT found metformin induced dietary restriction-like gene expression changes in overweight adults.
What happened
This 6-month randomised trial enrolled 60 overweight adults into metformin treatment, standard diet, or calorie restriction groups (20 per group). Researchers measured blood and muscle samples to assess whether metformin induces a dietary restriction-like gene expression state in humans, prompted by prior animal studies and observational associations between metformin use and reduced cancer and cardiovascular disease risk.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- Limitations have not been recorded; consult the primary source.
Study design and sample
Rct; Human.
Overweight subjects
- Design
- Rct
- Sample
- 60
- Journal
- Xiang Guang-da
- Published
- Apr 26, 2016
Effect size
Not recorded.
Caveats
- Assessment: Superseded.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
Not recorded.
Previous evidence
See the Metformin timeline and recorded assessment for prior evidence.
Primary source
Cancel Death charts and briefs may be reproduced editorially with attribution to CancelDeath.com. This brief is generated from the primary recorded source facts and assessment. Its review status is shown below; verify quotations against the paper before publication.