Reporter brief
RCT testing lifestyle intervention plus metformin for frailty in older obese veterans
What happened
This RCT tested whether a combination of lifestyle intervention (weight loss and exercise) plus metformin was effective for reversing sarcopenic obesity and frailty in older obese Veterans. The abstract describes the study hypothesis and population but does not report results, sample sizes, or effect sizes.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- Limitations have not been recorded; consult the primary source.
Study design and sample
Rct; Human.
114 older Veterans with obesity (38 per group) recruited from Michael E. DeBakey Veterans Affairs Medical Center and surrounding community through clinic referrals, advertisements, mailings, and research registries. Mean age 72.8 years (SD 5.2). Population predominantly male: 101 males (88.6%), 13 females (11.4%). Race: 50 Black/African American (43.9%), 64 White (56.1%). Ethnicity: 15 Hispanic/Latino (13.2%), 99 Not Hispanic/Latino (86.8%).
- Design
- Rct
- Sample
- 114
- Journal
- VA Office of Research and Development
- Published
- Sep 14, 2026
Effect size
Not recorded.
Caveats
- Assessment: Superseded.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
VA Office of Research and Development (indicated by journal affiliation)
Previous evidence
See the Metformin timeline and recorded assessment for prior evidence.
Primary source
Cancel Death charts and briefs may be reproduced editorially with attribution to CancelDeath.com. This brief is generated from the primary recorded source facts and assessment. Its review status is shown below; verify quotations against the paper before publication.