Reporter brief
Resistance training trial tests whether exercise mitigates muscle loss in transgender women receiving estrogen therapy
What happened
This prospective pilot RCT randomized participants initiating or recently initiated on estrogen-dominant gender-affirming hormone therapy 1:1 to a 12-week at-home resistance exercise intervention or control (nutritional and exercise counseling only). Muscle mass, strength, and function were assessed before and after the intervention period, with survey measures of gender congruence also collected.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- Limitations have not been recorded; consult the primary source.
Study design and sample
Rct; Human.
Transgender women and gender-diverse individuals about to be initiated or recently initiated (≤3 months ago) on estrogen-dominant gender-affirming hormone therapy
- Design
- Rct
- Sample
- —
- Journal
- Massachusetts General Hospital
- Published
- Sep 11, 2026
Effect size
Not recorded.
Caveats
- Assessment: Superseded.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
Not recorded.
Previous evidence
See the Resistance training timeline and recorded assessment for prior evidence.
Primary source
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