Reporter brief
Six-month HIIT associated with changes in DNA methylation-based aging measures in adults 50-70 years old
What happened
This observational study examined whether exercise volume from a 6-month supervised high-intensity interval training program was associated with changes in DNA methylation-based biological aging measures and other physiological markers in adults aged 50-70 years. Participants completed three supervised sessions weekly, with training intensity individually prescribed and monitored. The study assessed multiple biological aging clocks (DNAmFitAge, DNAmPhenoAge, DNAmGrimAge, Hannum Age, DunedinPACE, and others) along with cardiovascular function, aerobic capacity, muscle performance, body composition, metabolic biomarkers, and gut microbiome composition before and after the intervention.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- Limitations have not been recorded; consult the primary source.
Study design and sample
Cohort; Human.
Adults aged 50-70 years
- Design
- Cohort
- Sample
- —
- Journal
- Hungarian University of Sports Science
- Published
- Sep 2, 2026
Effect size
Not recorded.
Caveats
- Assessment: Superseded.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
Not recorded.
Previous evidence
See the VO2 max training timeline and recorded assessment for prior evidence.
Primary source
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