Reporter brief
Systematic review finds testosterone signaling affects cardiovascular disease through multiple mechanisms
What happened
This systematic review examined the relationship between androgens (particularly testosterone) and cardiovascular disease in aging adults. The authors surveyed the literature on testosterone's genomic and non-genomic signaling mechanisms in the cardiovascular system and reviewed evidence on how exogenous testosterone treatment and androgen deprivation therapy affect cardiovascular outcomes. The review identified associations between androgen levels and various cardiovascular conditions including cardiac hypertrophy, heart failure, atherosclerosis, aortic valve disease, and aneurysms.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- Limitations have not been recorded; consult the primary source.
Study design and sample
Systematic review; Unknown.
The review addresses androgen physiology and cardiovascular disease relationships in adults of varying ages, with particular attention to aging adults and consideration of both males and females; specific demographic details are not provided in the abstract.
- Design
- Systematic review
- Sample
- —
- Journal
- Cardiovascular engineering and technology
- Published
- Sep 17, 2026
Effect size
Not recorded.
Caveats
- Assessment: Superseded.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
Not recorded.
Previous evidence
See the Testosterone therapy timeline and recorded assessment for prior evidence.
Primary source
Cancel Death charts and briefs may be reproduced editorially with attribution to CancelDeath.com. This brief is generated from the primary recorded source facts and assessment. Its review status is shown below; verify quotations against the paper before publication.