Reporter brief
Systematic review maps cellular senescence regulatory network and emerging theranostic approaches
What happened
This systematic review examines the molecular mechanisms orchestrating cellular senescence, including the p53/p21 and p16/RB pathways, mitochondrial stress, and SASP programs, and how these are altered across cancer, metabolic, skeletal, and degenerative diseases. The authors discuss emerging theranostic strategies combining detection and intervention—such as enzyme-activatable prodrugs targeting senescence markers, smart nanocarriers, and engineered immune cells—alongside new methods for quantifying senescent burden in vivo.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- Limitations have not been recorded; consult the primary source.
Study design and sample
Systematic review; Unknown.
Not recorded.
- Design
- Systematic review
- Sample
- —
- Journal
- ACS Biomaterials Science & Engineering
- Published
- Sep 15, 2026
Effect size
Not recorded.
Caveats
- Assessment: Superseded.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
Not recorded.
Previous evidence
See the Senolytics timeline and recorded assessment for prior evidence.
Primary source
Cancel Death charts and briefs may be reproduced editorially with attribution to CancelDeath.com. This brief is generated from the primary recorded source facts and assessment. Its review status is shown below; verify quotations against the paper before publication.