Reporter brief
Systematic review: mTOR pathway integrates aging hallmarks; causal lifespan effects shown in model organisms, human evidence associative.
What happened
This systematic review examined mTOR signaling as a hub coordinating aging processes across genetic, experimental, and translational studies. In model organisms, mTOR pathway inhibition shows causal effects on lifespan regulation, whereas human data remain predominantly observational and associative. The review identifies mTOR as an integrative node linking multiple aging hallmarks and notes that major geroprotective interventions—including autophagy activation, dietary changes, physical activity, and senotherapeutics—partly converge on but also diverge from mTOR pathway modulation.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- Limitations have not been recorded; consult the primary source.
Study design and sample
Systematic review; Unknown.
Not recorded.
- Design
- Systematic review
- Sample
- —
- Journal
- Aging
- Published
- Sep 19, 2026
Effect size
Not recorded.
Caveats
- Assessment: Superseded.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
Not recorded.
Previous evidence
See the Rapamycin timeline and recorded assessment for prior evidence.
Primary source
Cancel Death charts and briefs may be reproduced editorially with attribution to CancelDeath.com. This brief is generated from the primary recorded source facts and assessment. Its review status is shown below; verify quotations against the paper before publication.