Reporter brief
Systematic review of sex and age differences in ischemic stroke molecular pathology and therapeutic response
What happened
This systematic review examined how biological sex and aging shape molecular mechanisms in ischemic stroke, emphasizing sex-specific cell death pathways, mitochondrial dysfunction, and NAD+-sirtuin signaling. The authors describe how premenopausal females show caspase-dependent apoptosis while males exhibit PARP-1-mediated parthanatos, and how postmenopausal females lose neuroprotective advantages due to estrogen receptor changes and mitochondrial decay. The review proposes precision medicine approaches including ER-alpha modulators, NAD+ precursors, and senolytic combinations tailored to sex and reproductive stage.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- Limitations have not been recorded; consult the primary source.
Study design and sample
Systematic review; Human.
Humans with ischemic stroke across the lifespan, stratified by biological sex and reproductive age
- Design
- Systematic review
- Sample
- —
- Journal
- Progress in Neurobiology
- Published
- Sep 16, 2026
Effect size
Not recorded.
Caveats
- Assessment: Pending.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
Not reported · Not reported
Previous evidence
See the NMN timeline and recorded assessment for prior evidence.
Primary source
Cancel Death charts and briefs may be reproduced editorially with attribution to CancelDeath.com. This brief is generated from the primary recorded source facts and assessment. Its review status is shown below; verify quotations against the paper before publication.