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Reporter brief

The Efficacy and Safety of a Mental Intervention Program vs. Usual Care and Nicotinamide Riboside (NR) vs. Placebo for Improving Health-related Quality of Life in Long Covid: A 2 x 2 Factorial Randomized Controlled Trial

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Trial registry update: COMPLETED. No results reported in the supplied registry record.

Assessment pending; this report does not establish a change in evidence.

  • The study protocol describes planned methodology but provides no results, so no efficacy of NR or MBRT can be determined from this text
  • The 2x2 factorial design allows comparison of NR versus placebo and MBRT versus usual care, but the text does not report whether either intervention improved quality of life or secondary outcomes
  • The explorative objectives including subgroup effects, mediators, and predictors are listed as planned analyses but no findings are presented

Rct; Human.

Individuals (18-70 years) with confirmed Long COVID interfering negatively with daily activities

Design
Rct
Sample
310
Journal
University Hospital, Akershus
Published
Aug 25, 2026

Not recorded.

  • Assessment: Unassessed.
  • Only the source material recorded on this evidence page was assessed.

Not recorded.

See the Nicotinamide riboside timeline and recorded assessment for prior evidence.

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Reporter brief: The Efficacy and Safety of a Mental Intervention Program vs. Usual Care and Nicotinamide Riboside (NR) vs. Placebo for Improving Health-related Quality of Life in Long Covid: A 2 x 2 Factorial Randomized Controlled Trial · Cancel Death