USP22 protein reduces senescence in bone marrow stem cells exposed to oxidative stress in vitro
This in vitro study examined how USP22 affects bone marrow mesenchymal stem cells (BMSCs) exposed to hydrogen peroxide to simulate oxidative stress. Researchers found that USP22 stabilized the SPI1 protein through deubiquitination, which increased NAMPT expression and NAD+ levels, reducing cellular senescence markers and preserving the cells' capacity to differentiate into bone tissue.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 17, 2026 · Discovered: Sep 17, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- In vitro
- Sample size
- —
- Duration
- —
- Population
- Bone marrow mesenchymal stem cells (BMSCs); ovariectomy-induced osteoporotic rat model
- Primary outcome
- USP22 alleviates oxidative stress-induced BMSCs senescence
- Effect size
- —
- Significance
- Not reported
- Journal
- Molecular genetics and genomics : MGG
- Published
- Sep 17, 2026
Sources
Primary source
- Molecular genetics and genomics : MGG ↗Peer reviewed
Assessment history
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