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- Observational study· The journal of nutrition, health & aging
Epigenetic age acceleration associated with increased pancreatic disease risk in UK Biobank cohort
In 326,873 UK Biobank participants, two measures of biological age acceleration (KDMAgeAccel and PhenoAgeAccel) were associated with increased risk of pancreatic diseases. The highest acceleration group (G4) had 1.7–3.6 times higher hazard ratios across pancreatic outcomes compared to the lowest group (G1), with the strongest associations for chronic pancreatitis (HR 3.551). Circulating lipid biomarkers partially mediated these associations, accounting for 6–9% of the effect.
Evidence assessment pending · COHORT
Read the study · The journal of nutrition, health & aging ↗ - Observational study· Health science reports
Epigenetic aging measures associated with higher mortality in breast cancer cohort study
This cohort study of 399 breast cancer patients from NHANES (1999-2020) examined whether three biological age indicators—calculated from 12 blood-based biomarkers—predicted all-cause mortality over a median 6.67-year follow-up. During this period, 144 deaths occurred. All three measures showed associations with increased mortality: Homeostatic Dysregulation (HR=1.465), Klemera-Doubal Method (HR=1.017), and Phenotypic Age (HR=1.080). Homeostatic Dysregulation performed better for short-term prediction while Phenotypic Age showed better efficacy for longer-term prediction.
Evidence assessment pending · COHORT
Read the study · Health science reports ↗ - Observational study· Journal of behavioral medicine
Threat-related early adversity associated with impaired danger-safety discrimination in adolescents
This observational study of 168 youth examined whether different types of early life adversity (threat vs. deprivation) were associated with fear responses and accelerated biological aging. Threat-related adversity was associated with impaired discrimination between danger and safety cues during fear conditioning and with greater left amygdala activation to negative stimuli. However, the study found no evidence that fear responses explained the link between threat and accelerated biological aging (advanced puberty or epigenetic age).
Evidence assessment pending · OBSERVATIONAL
Read the study · Journal of behavioral medicine ↗