Growth hormone
Prescription · Evidence and recent research
Notify me when meaningful evidence changes.
Where things stand
Replacing a diagnosed hormone deficiency is different from giving growth hormone to counter normal ageing. Endocrine guidance does not establish growth-hormone enhancement as an anti-ageing intervention. Changes in body composition alone are not enough to demonstrate better health or longer life, and treatment effects and harms must be assessed together. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged.
AI-written overview · not expert-reviewed · Background sources checked Sep 23, 2026 · Recent updates cover the last 30 days of this collection. A new report does not automatically change the evidence assessment.
⚠ Prescription or off-label use
Approved for specific deficiencies only. Evidence points toward reduced growth hormone signalling being associated with longer life, not increased.
Background and coverage
Endocrine Society: hormones and ageing ↗
- Regulatory status
- Approved other indication
- Availability
- Prescription only
- Category
- Prescription
- Human results verified here
- 0
Evidence collection is needs review. 0 approved assessments; 36 assessments awaiting review; 0 published studies with verified results. Safety: not assessed.
Recorded evidence activity (experimental)
A numeric breakdown will be available after baseline review. Safety is not yet assessed.
What changed
Evidence events affecting this intervention
Systematic review describes growth hormone receptor signaling mechanisms and Laron syndrome as a model of GH deficiency effects.
This systematic review examines the growth hormone-IGF-I axis and its role in growth, metabolism, and tissue homeostasis. The review synthesizes knowledge of growth hormone receptor structure, signal transduction pathways (JAK2-STAT5, MAPK/ERK, PI3K-AKT-mTOR), and discusses Laron syndrome—a condition of lifelong GHR deficiency—as a human model showing that GH deficiency associates with short stature but also enhanced insulin sensitivity, preserved glucose homeostasis, increased adiposity, and low cancer incidence.
Assessment history
The 25 most recent recorded changes, including corrections and backfill
Human studies with verified results
No published human results verified in this collection yet
Animal and mechanistic evidence
No preclinical studies tracked yet
Claims
Testable statements and where the evidence stands