Intermittent fasting

Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.

Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.

This systematic review examined mTOR signaling as a hub coordinating aging processes across genetic, experimental, and translational studies. In model organisms, mTOR pathway inhibition shows causal effects on lifespan regulation, whereas human data remain predominantly observational and associative. The review identifies mTOR as an integrative node linking multiple aging hallmarks and notes that major geroprotective interventions—including autophagy activation, dietary changes, physical activity, and senotherapeutics—partly converge on but also diverge from mTOR pathway modulation.

This is a protocol paper describing a planned 12-week randomized controlled trial (THYME study) comparing time-restricted eating (10-hour daytime eating window) versus nutrition counseling in 132 adults aged 55+ with prostate or metastatic breast cancer. The study aims to assess effects on fatigue, frailty, and circadian rhythm markers, with planned follow-up at 12 weeks and 12 months. No results from the trial are reported in this abstract—only the study design and hypotheses are presented.

DiAL Health is a 24-week randomized controlled pilot trial enrolling 90 healthy adults aged 22–45 into five groups: nonintervention control, traditional or adaptive time-restricted eating (8-hour window), and traditional or adaptive caloric restriction (25% energy reduction). Adaptive interventions used mobile health technology with real-time monitoring and personalized feedback; traditional interventions used in-person counseling. Primary outcomes were feasibility measures (adherence, retention, satisfaction); secondary outcomes included biological age (Klemera-Doubal) and metabolic syndrome score. No efficacy results have been reported yet.