Omega-3 fatty acids
Accessible · Evidence and recent research
Notify me when meaningful evidence changes.
Where things stand
Omega-3 fatty acids are studied for cardiovascular health, but results vary across populations and preparations. Prescription products, ordinary fish-oil supplements and eating fish are not interchangeable interventions. The useful question is which product improves which clinical outcome in which population, rather than assuming that a change in blood fats means a general longevity benefit. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged.
AI-written overview · not expert-reviewed · Background sources checked Sep 23, 2026 · Recent updates cover the last 30 days of this collection. A new report does not automatically change the evidence assessment.
Background and coverage
- Regulatory status
- Supplement
- Availability
- Widely available
- Category
- Accessible
- Human results verified here
- 0
Evidence collection is needs review. 0 approved assessments; 21 assessments awaiting review; 0 published studies with verified results. Safety: not assessed.
Recorded evidence activity (experimental)
A numeric breakdown will be available after baseline review. Safety is not yet assessed.
What changed
Evidence events affecting this intervention
Effectiveness of a Combined Physical Exercise and Olive Oil Supplementation Intervention (VIVI-OLIVE) on Fall Risk in Frail Community-Dwelling Patients at High Risk of Falls: A Multicenter Randomized Clinical Trial
Trial registry update: RECRUITING. No results reported in the supplied registry record.
A Double-Blind, Randomised, Placebo-Controlled Study Evaluating the Effects of a Novel Multi-Targeted Dermatologist-Formulated Oral Supplement on Skin, Hair, Sleep, Energy, Cognition, Libido, and Longevity
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
VIVI-OLIVE RCT of exercise plus olive oil supplementation for fall risk in older adults
VIVI-OLIVE is a multicenter randomized trial testing a 24-month intervention combining multicomponent exercise (VIVIFRAIL), Mediterranean diet counselling, and 60 mL/day extra virgin olive oil supplementation versus control exercise alone in adults aged 75+ at high risk of falls. The primary outcome is change in usual gait speed; secondary outcomes include physical function, functional independence, falls, and fall-related consequences.
Fish oil with metformin did not yet reduce atherosclerosis markers in women with PMOS: RCT protocol.
This is a protocol paper describing a planned RCT, not results from a completed trial. The study will randomize 146 overweight or obese women aged 25-45 with PMOS and elevated triglycerides or apoB to receive either fish oil (5.96 g/day) or placebo for 12 months alongside standard metformin therapy. Primary outcomes are carotid intimal-medial thickness, carotid plaque height, and left ventricular strain; secondary outcomes include blood lipids and glucose-insulin measures.
Multi-ingredient supplement including omega-3s in 12-week RCT showed mixed effects on skin and self-reported outcomes.
A 12-week double-blind randomised controlled trial tested a multi-ingredient supplement regimen (containing omega-3 fatty acids plus collagen and other components) versus placebo in 35–65 year-olds. Outcomes included skin measurements, hair imaging, cognitive testing, and participant-reported sleep, energy, cognition, and sexual wellbeing. The abstract does not report which outcomes showed differences between groups or the direction or magnitude of effects.
Systematic review describes nutritional interventions, including omega-3s, as potential modulators of aging-related immune dysfunction.
This systematic review examines how nutritional interventions—including bioactive compounds, essential nutrients, and functional foods—might modulate immune system aging (immunosenescence) and its effects on organ function. The authors propose an "immune-organ axis" framework linking immune dysregulation to organ-specific dysfunction in conditions like neurodegeneration and chronic inflammation. The review highlights antioxidants from sources like fish oil, berries, turmeric, and algae as potentially beneficial, while noting that bioactive compounds face absorption and stability challenges.
Assessment history
The 25 most recent recorded changes, including corrections and backfill
Human studies with verified results
No published human results verified in this collection yet
Animal and mechanistic evidence
No preclinical studies tracked yet
Clinical trials
Claims
Testable statements and where the evidence stands