Spermidine
Accessible · Evidence and recent research
Notify me when meaningful evidence changes.
Where things stand
Spermidine is being investigated as a possible way to influence cellular maintenance. Human supplement research includes small, short trials, such as a study examining tolerability and blood chemistry over weeks. Such work can inform further trials, but it cannot establish prevention of age-related disease, long-term safety or life extension. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged.
AI-written overview · not expert-reviewed · Background sources checked Sep 23, 2026 · Recent updates cover the last 30 days of this collection. A new report does not automatically change the evidence assessment.
Background and coverage
Spermidine randomized human trial ↗
- Regulatory status
- Supplement
- Availability
- Widely available
- Category
- Accessible
- Human results verified here
- 0
Evidence collection is needs review. 0 approved assessments; 4 assessments awaiting review; 0 published studies with verified results. Safety: not assessed.
Recorded evidence activity (experimental)
A numeric breakdown will be available after baseline review. Safety is not yet assessed.
What changed
Evidence events affecting this intervention
A Phase 1b, Multi-cohort Clinical Trial Assessing Safety and Feasibility of Exercise and Spermidine Administered in Conjunction With Lamivudine (RTi) or Rapamycin (mTORi) to Assess Impact on Dynamic Changes of Inflammation and Aging
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Exercise combined with spermidine and rapamycin or lamivudine was feasible in Phase 1b trial
This Phase 1b RCT assessed the safety and feasibility of combining exercise, spermidine supplementation, and either rapamycin or lamivudine in participants. The study evaluated whether this multi-component intervention could be delivered as designed and was tolerated, as a precursor to testing effects on inflammation and aging markers.
Assessment history
The 25 most recent recorded changes, including corrections and backfill
Human studies with verified results
No published human results verified in this collection yet
Animal and mechanistic evidence
No preclinical studies tracked yet