Registry update — unassessed
COVID-FIS: A Phase 2 Placebo-Controlled Pilot Study in COVID-19 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Older Adults in Nursing Homes
Trial registry update: TERMINATED. Results are posted in the registry; assessment pending.
RCTNotable significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Aug 26, 2025 · Discovered: Sep 16, 2026 · Assessed: — · Historical research backfill
What it does not prove
- No results are reported in the abstract, making it impossible to assess whether the intervention actually worked or produced clinical benefit in this population
- The study design and phase do not establish whether any observed effect would generalize beyond nursing home residents or persist beyond the acute COVID-19 episode
- The mechanism by which fisetin might work in acute COVID-19 infection is not addressed; senolytic effects on chronic age-related pathology may differ from effects during active viral infection
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- —
- Population
- Older adults in nursing homes with COVID-19
- Primary outcome
- Prevention of disease progression and alleviation of complications due to excessive inflammatory response in COVID-19
- Effect size
- —
- Significance
- Not reported
- Journal
- Mayo Clinic
- Published
- Aug 26, 2025
Sources
Primary source
- Mayo Clinic ↗Clinical trial
Recorded source passages
Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.
COVID-FIS: A Phase 2 Placebo-Controlled Pilot Study in COVID-19 of Fisetin to Alleviate Dysfunction and Excessive Inflammatory Response in Older Adults in Nursing Homes
The purpose of this study is to test whether Fisetin, a senolytic drug, can assist in preventing an increase in the disease's progression and alleviate complications of coronavirus due to an excessive inflammatory reaction.
Source versions
Assessment history
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