Reporter brief
Dasatinib and quercetin reduced radiation-induced atrial fibrillation in mice via senescence pathway suppression
What happened
This preclinical study used mice exposed to 20 Gy cardiac irradiation to investigate radiation-induced atrial fibrillation. Irradiation triggered DNA damage, cellular senescence, and atrial remodeling through GATA4-NF-κB signaling. Treatment with the senolytic combination dasatinib and quercetin suppressed this pathway, reduced senescence markers, and reversed atrial remodeling with decreased susceptibility to atrial fibrillation.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- Limitations have not been recorded; consult the primary source.
Study design and sample
Preclinical; Animal.
In vivo: irradiated mice with localized cardiac irradiation; in vitro: irradiated HL-1 atrial cardiomyocytes
- Design
- Preclinical
- Sample
- —
- Journal
- International immunopharmacology
- Published
- Sep 15, 2026
Effect size
Not recorded.
Caveats
- Assessment: Superseded.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
Not recorded.
Previous evidence
See the Senolytics timeline and recorded assessment for prior evidence.
Primary source
Cancel Death charts and briefs may be reproduced editorially with attribution to CancelDeath.com. This brief is generated from the primary recorded source facts and assessment. Its review status is shown below; verify quotations against the paper before publication.