Reporter brief
Emotional neglect trauma associated with lower Klotho and cognitive deficits in adolescents with mood disorders: observational study.
What happened
This observational study enrolled 95 adolescents with bipolar or major depressive disorder and 45 healthy controls, identifying three trauma-based subgroups through cluster analysis. Adolescents in the emotional neglect-focused trauma group had lower serum Klotho levels, higher MMP-9 levels, and worse performance on working memory and executive function tests compared to other groups and controls.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- Limitations have not been recorded; consult the primary source.
Study design and sample
Observational; Human.
95 adolescents with major affective disorders (48 bipolar disorder, 47 major depressive disorder) and 45 healthy controls
- Design
- Observational
- Sample
- 140
- Journal
- Neuropsychobiology
- Published
- Sep 21, 2026
Effect size
Not recorded.
Caveats
- Assessment: Pending.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
Not recorded.
Previous evidence
See the Klotho timeline and recorded assessment for prior evidence.
Primary source
Cancel Death charts and briefs may be reproduced editorially with attribution to CancelDeath.com. This brief is generated from the primary recorded source facts and assessment. Its review status is shown below; verify quotations against the paper before publication.