Epigenetic age acceleration not associated with cardiorespiratory fitness in 14 heart failure patients.
This observational pilot study analyzed DNA methylation epigenetic clocks in blood samples from 14 heart failure patients to assess whether biological age acceleration predicted cardiorespiratory fitness. While biological age showed correlations with fitness measures, chronological age performed equally well, and epigenetic age acceleration was not significantly associated with any fitness parameter. Epigenetic clocks did not add predictive value beyond chronological age alone.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 17, 2026 · Discovered: Sep 17, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Observational
- Sample size
- 14
- Duration
- —
- Population
- Patients with heart failure (HF) enrolled in REDHART2, a clinical trial of interleukin-1 blockade following hospitalization for acute systolic HF
- Primary outcome
- Association between epigenetic age acceleration (EAA) and cardiorespiratory fitness measures in patients with heart failure
- Effect size
- —
- Significance
- Not significant
- Journal
- Epigenomics
- Published
- Sep 17, 2026
Sources
Primary source
- Epigenomics ↗Peer reviewed
Assessment history
9/23/2026 · SUPERSEDED: Source updated; assessment withdrawn pending review.
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