Epigenetic aging measures associated with higher mortality in breast cancer cohort study
This cohort study of 399 breast cancer patients from NHANES (1999-2020) examined whether three biological age indicators—calculated from 12 blood-based biomarkers—predicted all-cause mortality over a median 6.67-year follow-up. During this period, 144 deaths occurred. All three measures showed associations with increased mortality: Homeostatic Dysregulation (HR=1.465), Klemera-Doubal Method (HR=1.017), and Phenotypic Age (HR=1.080). Homeostatic Dysregulation performed better for short-term prediction while Phenotypic Age showed better efficacy for longer-term prediction.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 13, 2026 · Discovered: Sep 15, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Cohort
- Sample size
- 399
- Duration
- 80 months
- Population
- Breast cancer participants from the National Health and Nutrition Examination Survey (NHANES) 1999-2020
- Primary outcome
- All-cause mortality in breast cancer patients
- Effect size
- HD (HR = 1.465, 95% CI: 1.169-1.836); KDM (HR = 1.017, 95% CI: 1.004-1.030); PA (HR = 1.080, 95% CI: 1.023-1.140)
- Significance
- Significant
- Journal
- Health science reports
- Published
- Sep 13, 2026
Sources
Primary source
- Health science reports ↗Peer reviewed
Assessment history
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