Reporter brief
Evaluating the Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans: An Interventional, Non-Placebo-Controlled Pilot Phase Study
What happened
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Why it matters
Assessment pending; this report does not establish a change in evidence.
What it does NOT prove
- Absence of a placebo control means any perceived benefits cannot be distinguished from placebo effect or natural variation.
- The lack of a comparison group prevents determining whether observed outcomes differ from untreated healthy volunteers.
- Safety in this small pilot does not establish safety or efficacy in broader populations or in people with disease.
Study design and sample
Observational; Human.
Healthy adult volunteers
- Design
- Observational
- Sample
- —
- Journal
- Minicircle
- Published
- Aug 27, 2026
Effect size
Not recorded.
Caveats
- Assessment: Unassessed.
- Only the source material recorded on this evidence page was assessed.
Conflicts and funding
Not recorded.
Previous evidence
See the Klotho timeline and recorded assessment for prior evidence.
Primary source
Cancel Death charts and briefs may be reproduced editorially with attribution to CancelDeath.com. This brief is generated from the primary recorded source facts and assessment. Its review status is shown below; verify quotations against the paper before publication.