Registry update — unassessed
Evaluating the Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans: An Interventional, Non-Placebo-Controlled Pilot Phase Study
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
OBSERVATIONALMinor significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Aug 27, 2026 · Discovered: Sep 15, 2026 · Assessed: — · Research update
What it does not prove
- Absence of a placebo control means any perceived benefits cannot be distinguished from placebo effect or natural variation.
- The lack of a comparison group prevents determining whether observed outcomes differ from untreated healthy volunteers.
- Safety in this small pilot does not establish safety or efficacy in broader populations or in people with disease.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Observational
- Sample size
- —
- Duration
- —
- Population
- Healthy adult volunteers
- Primary outcome
- Safety and efficacy of Klotho gene therapy
- Effect size
- —
- Significance
- Not reported
- Journal
- Minicircle
- Published
- Aug 27, 2026
Sources
Primary source
- Minicircle ↗Clinical trial
Recorded source passages
Abstract or registry material supplied for assessment; source version 2. This is not a claim of full-text review.
Evaluating the Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans: An Interventional, Non-Placebo-Controlled Pilot Phase Study
The purpose of this study is to investigate the safety and efficacy of a gene therapy for Klotho, delivered via a nonviral plasmid in healthy adult volunteers. Additionally, this study seeks to understand the cognitive and health benefits of the Klotho gene therapy.
Source versions
Assessment history
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