Klotho
Frontier · Evidence and recent research
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Where things stand
Klotho is a protein studied for links with ageing and brain function. Giving it to aged rhesus monkeys improved performance on a memory task in a small experimental study. That is an animal cognition result, not evidence of human life extension; clinical benefit, delivery and safety in people are separate questions. Source ↗ Recently: No update dated within the past 30 days is recorded in our collection. This describes our coverage, not a conclusion that the wider research is unchanged.
AI-written overview · not expert-reviewed · Background sources checked Sep 23, 2026 · Recent updates cover the last 30 days of this collection. A new report does not automatically change the evidence assessment.
Background and coverage
Nature Aging: klotho in aged primates ↗
- Regulatory status
- Investigational
- Availability
- Not available
- Category
- Frontier
- Human results verified here
- 1
Evidence collection is needs review. 0 approved assessments; 61 assessments awaiting review; 1 published studies with verified results. Safety: not assessed.
Recorded evidence activity (experimental)
A numeric breakdown will be available after baseline review. Safety is not yet assessed.
What changed
Evidence events affecting this intervention
Evaluating the Safety and Efficacy of Injectable Combination Klotho and Follistatin Plasmid Gene Therapy in Humans -- An Interventional, Non-Placebo Controlled Pilot Phase Study
Trial registry update: COMPLETED. No results reported in the supplied registry record.
Evaluating the Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans: An Interventional, Non-Placebo-Controlled Pilot Phase Study
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
Emotional neglect trauma associated with lower Klotho and cognitive deficits in adolescents with mood disorders: observational study.
This observational study enrolled 95 adolescents with bipolar or major depressive disorder and 45 healthy controls, identifying three trauma-based subgroups through cluster analysis. Adolescents in the emotional neglect-focused trauma group had lower serum Klotho levels, higher MMP-9 levels, and worse performance on working memory and executive function tests compared to other groups and controls.
Systematic review finds platelet factor 4 modulates cognitive, immune, and hematopoietic aging through multiple signaling pathways.
This systematic review examined evidence for platelet factor 4 (PF4) in age-related dysfunction across cognitive, immune, and hematopoietic systems. The authors report that PF4 engages CXCR3 and LDLR receptors to activate downstream signaling, with reported effects including reduced hippocampal neuroinflammation, enhanced synaptic plasticity, restored T-cell balance, and preserved hematopoietic stem cell function in aging. Clinical observational studies identified correlations between circulating PF4 levels and conditions including Alzheimer's disease, sarcopenia, stroke, and coronary artery disease.
Klotho levels associated with bone density in women with systemic sclerosis: observational cross-sectional study
This observational cross-sectional study examined whether klotho and related cytokines are associated with bone mineral density and osteoimmunological markers in female patients aged 45-65 with systemic sclerosis, compared to age and gender-matched healthy controls. The study investigates whether these factors relate to the microvascular damage and fibrosis characteristic of systemic sclerosis. No effect sizes, sample sizes, or specific findings are reported in the abstract.
Klotho gene therapy safety and efficacy tested in healthy adults without control group.
An interventional pilot study investigated safety and efficacy of injectable Klotho plasmid gene therapy in healthy adult volunteers. The study was non-placebo-controlled. Sample size and effect size were not reported in the available information.
Injectable klotho-follistatin plasmid gene therapy assessed for safety in healthy adults in uncontrolled pilot study
This pilot study investigated the safety and efficacy of a combination klotho and follistatin gene therapy delivered via nonviral plasmid injection in healthy adult volunteers. The study sought to evaluate both safety outcomes and potential cognitive and health benefits, though no specific results are reported in the abstract.
Assessment history
The 25 most recent recorded changes, including corrections and backfill
Human studies with verified results
Animal and mechanistic evidence
No preclinical studies tracked yet
Clinical trials
Claims
Testable statements and where the evidence stands