Registry update — unassessed
Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults
Trial registry update: RECRUITING. No results reported in the supplied registry record.
RCTMinor significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Oct 7, 2026 · Discovered: Oct 7, 2026 · Assessed: — · Research update
What it does not prove
- This is a study protocol or prospective registration with no outcome data; no claims about efficacy or safety can be evaluated.
- The crossover design and comparison between two active interventions (NMN+TMG vs NMN alone) means any positive findings would not establish superiority over placebo for either formulation.
- Sample size, statistical power, and recruitment/completion status are not disclosed, making it impossible to assess whether findings would be statistically reliable.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- —
- Population
- Healthy older adults
- Primary outcome
- Cycle ergometry constant work rate (CWR) exercise tolerance, measured as time to fatigue
- Effect size
- —
- Significance
- Not reported
- Journal
- Not clearly reported
- Published
- Oct 7, 2026
Sources
Primary source
- Scott Silveira ↗Clinical trial
Recorded source passages
Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.
This is a randomized, double-blind, placebo-controlled, two-arm crossover clinical trial evaluating the effects of nicotinamide mononucleotide (NMN) combined with trimethylglycine (TMG) supplementation, compared to NMN alone.
The primary outcome is cycle ergometry constant work rate (CWR) exercise tolerance, measured as time to fatigue. Secondary outcomes include changes in peak oxygen consumption (VO₂peak), critical power, anaerobic work capacity, lactate threshold, and NAD⁺ metabolite levels.
Assessment history
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