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Nicotinamide riboside
Registry update — unassessed

Nicotinamide Riboside to Improve Functioning in PAD

Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.

RCTN=250Notable significance
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Reporter brief

What this changes

The finding has not established an approved change to our evidence assessment.

Source date: Aug 24, 2026 · Discovered: Sep 23, 2026 · Assessed: — · Historical research backfill

What it does not prove

  • The abstract presents only the study protocol, not results; no efficacy or safety conclusions can be drawn.
  • Without reported effect sizes or p-values, the magnitude or statistical significance of any treatment differences cannot be assessed.
  • Secondary outcomes including muscle perfusion, oxidative stress, and NAD+ levels are not reported here.

Extracted from supplied source material; model confidence is not a measured probability of correctness.

Study details

Design
Rct
Sample size
250
Duration
7 months
Population
People with peripheral artery disease (PAD) age 50 and older
Primary outcome
Change in six-minute walk distance at six-month follow-up
Effect size
—
Significance
Not reported
Journal
Northwestern University
Published
Aug 24, 2026

Sources

Primary source

Recorded source passages

Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.

Among people with peripheral artery disease (PAD) age 50 and older, the investigators will test the hypothesis that PAD participants randomized to nicotinamide riboside (NR) will have greater improvement or less decline in six-minute walk distance at six-month follow-up, compared to those randomized to placebo.
The study will randomize 250 participants with PAD age 50 and older to one of two groups for six months: nicotinamide riboside vs placebo.
Participants will be followed for six months, with an additional four-week follow-up period after completion of the study intervention.

Assessment history

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