Senolytic treatment effects on adipose tissue cells assessed by single-nuclei RNA sequencing in older obese adults

This randomized controlled trial compared senolytics, lifestyle intervention, and placebo in older obese participants. Researchers performed baseline and post-intervention biopsies of abdominal adipose tissue for single-nuclei RNA sequencing analysis and measured metabolic outcomes including insulin sensitivity, glucose tolerance, and beta-cell function. The abstract provided does not report the study's primary results or findings.