STING inhibitor H-151 extended lifespan and reduced aging phenotypes in progeroid mice.
Researchers studied the LMNA-CK2α-STING signaling axis in aging using mouse models of progeria. Pharmacologic STING inhibition (H-151) in vivo rescued progeroid phenotypes including bone density loss and multi-tissue senescence, and extended lifespan. The authors found that controlled attenuation of STING signaling was more effective than complete STING ablation.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Aug 19, 2026 · Discovered: Sep 17, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Preclinical
- Sample size
- —
- Duration
- —
- Population
- Progeroid mouse models; myeloid cells
- Primary outcome
- Lifespan extension in progeroid mouse models following pharmacologic STING inhibition
- Effect size
- Lifespan extension (specific magnitude not quantified in abstract); rescue of bone density loss and multi-tissue senescence
- Significance
- Significant
- Journal
- Nature Communications
- Published
- Aug 19, 2026
Sources
Primary source
- Nature communications ↗Peer reviewed
Assessment history
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