Systematic review proposes inflammaging as shared driver of osteoporosis and cognitive decline via bone-brain axis

This systematic review synthesizes evidence linking chronic low-grade inflammation (inflammaging) driven by senescent cells to concurrent skeletal aging and cognitive impairment. The authors propose that SASP-derived cytokines and inflammatory pathways (NF-κB, NLRP3) simultaneously drive bone resorption and neuroinflammation through the bone-brain axis, and discuss candidate interventions including senolytics, though they explicitly note most mechanisms rest on preclinical models or single cohorts lacking independent human validation.