Registry update — unassessed
The Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis
Trial registry update: UNKNOWN. No results reported in the supplied registry record.
RCTRoutine significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Apr 16, 2024 · Discovered: Sep 16, 2026 · Assessed: — · Historical research backfill
What it does not prove
- No efficacy or safety results are reported in the provided text, so no claims about whether these agents actually improve BMAC outcomes can be evaluated
- The study design is described prospectively but as an ongoing trial protocol rather than completed results, so clinical benefit remains unknown
- Without reported data on primary endpoints, sample size achieved, or participant characteristics, the evidentiary value of this trial cannot be assessed
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- —
- Population
- Patients with osteoarthritis of the knee
- Primary outcome
- Safety and efficacy of senolytic and anti-fibrotic agents in improving the beneficial effect of BMAC for osteoarthritis
- Effect size
- —
- Significance
- Not reported
- Journal
- Steadman Philippon Research Institute
- Published
- Apr 16, 2024
Sources
Primary source
- Steadman Philippon Research Institute ↗Clinical trial
Recorded source passages
Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.
This is a prospective, randomized, double-blind, active control clinical trial to evaluate the safety and efficacy of a senolytic agent (Fisetin) and an anti-fibrotic agent (Losartan), used independently and in combination, to improve beneficial effect demonstrated by the active control which is to be injection of autologous bone marrow aspirate concentrate (BMAC) into an osteoarthritic knee.
Source versions
Assessment history
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