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- Research review· Frontiers in immunology
Review discusses mechanisms of sarcopenia and potential therapeutic targets in the aging muscle microenvironment.
This is a review article that synthesizes evidence on the pathophysiology of sarcopenia, focusing on early changes in the muscle microenvironment rather than end-stage myofiber atrophy. The authors identify key mechanisms including dysregulated immunity, cellular senescence, satellite cell dysfunction, mitochondrial dysfunction, and impaired proteostasis. The review proposes that targeting these early alterations through exercise, nutrition, anti-inflammatory strategies, senescent cell clearance, and mitochondrial support may offer more effective therapeutic approaches than interventions addressing only late-stage muscle loss.
Evidence assessment pending · SYSTEMATIC REVIEW
Read the study · Frontiers in immunology ↗ - Observational study· Translational psychiatry
Healthy lifestyle associated with longer telomeres in severe mental disorders, observational study of 410 patients
This observational study of 410 individuals with schizophrenia spectrum or affective disorders examined whether lifestyle factors were associated with telomere length, a marker of cellular ageing. Participants reporting healthy lifestyles had significantly longer telomeres than those reporting unhealthy lifestyles (Cohen's d = 0.58, p = 0.004), with an apparent dose-response relationship between increasing unhealthy behaviours and shorter telomeres (p = 0.02). The observed difference corresponded to approximately 6 years of biological age.
Evidence assessment pending · OBSERVATIONAL
Read the study · Translational psychiatry ↗ - Observational study· Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Prolonged sedentary time with few breaks associated with higher cardiovascular mortality and CVD incidence in observational cohort.
This prospective cohort study of 89,010 UK Biobank participants with wearable accelerometer data found that prolonged sedentary time (≥10 hours/day) with infrequent breaks (<12 bouts/day) was associated with a 51.5% higher risk of all-cause mortality, 55.3% higher cardiovascular mortality risk, and 10% higher CVD incidence risk compared to the least sedentary group, during 8 years of follow-up. At age 50, this sedentary pattern was associated with loss of 2.8 years in men and 3.1 years in women of CVD-free life expectancy. More frequent interruptions to sedentary time attenuated these risks.
Evidence assessment pending · COHORT
Read the study · Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences ↗