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  1. Observational study· British dental journal

    Metformin and azithromycin lower acquisition costs than amoxicillin-metronidazole for periodontitis: cost analysis

    Published Sep 18, 2026Added 1moStart a discussionShare on XMetformin

    This observational cost comparison analysed 445 antibiotic prescriptions for periodontitis at a UK dental hospital between 2021-2024. Azithromycin reduced acquisition costs by 55% compared to guideline-recommended amoxicillin plus metronidazole (£2.81 per course). Non-antimicrobial adjuncts including metformin 500 mg achieved up to 91% cost reductions depending on treatment duration.

    Evidence assessment pending · OBSERVATIONAL

    Read the study · British dental journal ↗