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- Animal research· Signal transduction and targeted therapy
A liver protein declines with age and slows liver recovery in mice
Hepassocin (HPS), a protective protein made by the liver, decreases with aging in mice and elderly humans. When HPS was removed in aged mice, their livers showed more damage, slower recovery after injury, and impaired cellular cleanup; restoring HPS or activating its downstream pathway improved outcomes.
Why it matters: Age-related liver dysfunction increases disease risk and death, and identifying the molecular causes could lead to new treatments to restore liver health in older adults.
AI-assisted explanation · Evidence assessment pending
Read the study · Signal transduction and targeted therapy ↗ - Research paper· Tobacco induced diseases
Cigarette smoke triggers lung aging through a cellular stress pathway
Cigarette smoke activates a protein called aryl hydrocarbon receptor in lung cells, which causes damaging molecules to accumulate and impairs cells' cleaning systems, leading to permanent cellular aging linked to COPD.
Why it matters: Understanding this smoke-damage pathway could point to new targets for treating or slowing the lung disease caused by smoking.
AI-assisted explanation · Evidence assessment pending
Read the study · Tobacco induced diseases ↗