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- Trial registry · no verified findings· Genentech, Inc.
Phase IIa trial evaluates safety and feasibility of subretinal OpRegen stem cell delivery in geographic atrophy.
This Phase IIa open-label single-arm study assessed the surgical feasibility and safety of subretinal delivery of OpRegen (a stem cell therapy) in patients with geographic atrophy secondary to age-related macular degeneration. The trial also evaluated preliminary activity of the intervention. A substudy explored incorporation of advanced retinal imaging as an assessment tool.
Evidence assessment pending
Read the source · Genentech, Inc. ↗ - Trial registry · no verified findings· Mayo Clinic
Proposed RCT of fisetin on stem cell function and kidney outcomes in advanced chronic kidney disease
This is a proposed study protocol, not a completed trial. The researchers planned to examine whether fisetin would improve adipose tissue-derived mesenchymal stem/stromal cell function, kidney function, inflammation markers, and physical function in individuals with advanced chronic kidney disease. No results are reported because the study has not been conducted.
Evidence assessment pending
Read the source · Mayo Clinic ↗