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Metformin
Registry update — unassessed

A Pilot Randomized Controlled Study of Combinatorial Gerotherapeutics for Healthspan Improvement

Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.

RCTN=30Notable significance
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Reporter brief

What this changes

The finding has not established an approved change to our evidence assessment.

Source date: Mar 16, 2026 · Discovered: Sep 15, 2026 · Assessed: — · Historical research backfill

What it does not prove

  • The effect of metformin specifically cannot be isolated because it was used as part of multi-component treatment regimens rather than as a standalone intervention.
  • Whether any observed benefits persist beyond 90 days, as this was a short-term pilot study.
  • Whether the intervention improves actual lifespan or healthspan measures commonly used in aging research, as the outcomes measured are not specified in the available information.

Extracted from supplied source material; model confidence is not a measured probability of correctness.

Study details

Design
Rct
Sample size
30
Duration
3 months
Population
Small sample size pilot study; specific population characteristics not reported
Primary outcome
Longevity-related outcomes (not specifically defined)
Effect size
—
Significance
Not reported
Journal
AgelessRx
Published
Mar 16, 2026

Sources

Primary source

Recorded source passages

Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.

This study is a 90-day interventional, randomized, controlled pilot trial exploring multi-modal gerotherapies and their impact on longevity-related outcomes.
In this proof-of-concept phase, a small sample size of up to 30 subjects (10 subjects in each arm) will be randomized into one of the three arms: 1) Control, 2) Multi-therapy (B12, Naltrexone, Metformin, and NAD+), or 4) Comprehensive Therapy (Rapamycin, Naltrexone, Metformin, B12, NAD+, GSH, and Infinite Supplement).

Source versions

Version 1: Unassessed

Version 1: Superseded

Assessment history

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