Acute aerobic exercise associated with glymphatic function changes on MRI in cognitively unimpaired adults

This prospective observational study recruited cognitively unimpaired adults aged 25–55 and 55–75 years to examine whether acute aerobic exercise affects glymphatic function measured by multi-modal MRI. All enrolled subjects participated in an exercise session without randomization or control group. The study aimed to test whether elevated cardiac activity during exercise enhances cerebrospinal fluid-interstitial fluid exchange and whether glymphatic dysfunction increases with age and associates with preclinical Alzheimer's pathology.