VO2 max training

Trial registry update: RECRUITING. No results reported in the supplied registry record.

Trial registry update: COMPLETED. No results reported in the supplied registry record.

Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.

Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.

Trial registry update: COMPLETED. No results reported in the supplied registry record.

Trial registry update: RECRUITING. No results reported in the supplied registry record.

Trial registry update: COMPLETED. No results reported in the supplied registry record.

Trial registry update: COMPLETED. No results reported in the supplied registry record.

Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.

A meta-analysis of 14 randomized controlled trials (n=893, ages 30-94) examined the effect of exercise training on circulating α-Klotho. Chronic training (≥12 weeks) produced a pooled effect of Hedges' g=1.20 (95% CI 0.85-1.55). In chronic kidney disease patients specifically, exercise increased Klotho by 158.82 pg/mL and reduced FGF23 by 102.07 pg/mL. Resistance training and high-intensity interval training showed the most robust effects.

This is a registered clinical trial protocol that planned to examine how age affects skeletal muscle mitochondrial function and whether a 4-week home-based exercise intervention could alter this. The study compared high-intensity interval training (HIIT) to resistance training using bands in older participants.

This prospective observational study recruited cognitively unimpaired adults aged 25–55 and 55–75 years to examine whether acute aerobic exercise affects glymphatic function measured by multi-modal MRI. All enrolled subjects participated in an exercise session without randomization or control group. The study aimed to test whether elevated cardiac activity during exercise enhances cerebrospinal fluid-interstitial fluid exchange and whether glymphatic dysfunction increases with age and associates with preclinical Alzheimer's pathology.

PhActHealth is a multicenter RCT enrolling women with newly diagnosed luminal B or triple-negative breast cancer. Participants were randomly assigned to lifestyle counseling alone (control) or counseling plus a personalized aerobic and resistance exercise program during neoadjuvant treatment. The study measured exercise capacity as the primary outcome, with secondary outcomes including immune response, autonomic nervous system regulation, cardiovascular health, and tumor aggressiveness markers.

The ACTIONcardioRisk trial investigated the effect of combined aerobic exercise, progressive resistance training, and cognitive training on neurocognitive functioning in sedentary older adults with and without cardiovascular risk factors. The abstract does not report what effects were found, sample size, or effect sizes.

This observational study examined whether exercise volume from a 6-month supervised high-intensity interval training program was associated with changes in DNA methylation-based biological aging measures and other physiological markers in adults aged 50-70 years. Participants completed three supervised sessions weekly, with training intensity individually prescribed and monitored. The study assessed multiple biological aging clocks (DNAmFitAge, DNAmPhenoAge, DNAmGrimAge, Hannum Age, DunedinPACE, and others) along with cardiovascular function, aerobic capacity, muscle performance, body composition, metabolic biomarkers, and gut microbiome composition before and after the intervention.

This randomized controlled trial compared a 3-month progressive exercise program (aerobic and resistance training) plus standard care versus standard chemotherapy and nutritional counseling alone in patients aged 40-60 receiving neoadjuvant chemotherapy for non-metastatic cancer. The study measured biomarkers related to muscle-bone signaling (myokines and osteokines) and functional physical outcomes to assess whether targeted exercise could attenuate cachexia.

This is a randomized controlled trial comparing home-based aerobic exercise (AE), combined aerobic and resistance exercise (ARE), and control (physical activity counseling) in adult patients with chronic liver disease who have complications including sarcopenia, malnutrition, and fatigue. The 8-week intervention measured oxygen consumption, muscle strength, body composition, frailty, fatigue, and quality of life before and after the program. The abstract describes the study design and planned measurements but does not report the actual results or findings.

A randomized controlled trial tested a community-based physical exercise program in people aged 50 and older with multiple chronic diseases including cardiovascular disease, diabetes, or musculoskeletal disease. The program aimed to improve cardiorespiratory fitness, muscular strength, bone health, functional capacity, and quality of life through personalized exercise prescription. The abstract describes the study design and objectives but does not report the actual findings, effect sizes, or whether outcomes improved.

A randomized controlled trial assigned hemodialysis patients to one of three groups: aerobic exercise using a cycle ergometer, resistance exercise using elastic bands, or standard care. After 6 months, researchers assessed physical function, body composition, quality of life, and dialysis-related outcomes. The abstract does not report the actual results, sample size, or effect sizes.