RCT of physical therapy program shows exercise effects on cancer-induced cachexia biomarkers
This randomized controlled trial compared a 3-month progressive exercise program (aerobic and resistance training) plus standard care versus standard chemotherapy and nutritional counseling alone in patients aged 40-60 receiving neoadjuvant chemotherapy for non-metastatic cancer. The study measured biomarkers related to muscle-bone signaling (myokines and osteokines) and functional physical outcomes to assess whether targeted exercise could attenuate cachexia.
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 8, 2026 · Discovered: Sep 17, 2026 · Assessed: — · Research update
What it does not prove
- Limitations have not yet been verified. Read the primary source.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- 3 months
- Population
- Non-metastatic cancer patients aged 40–60 undergoing neoadjuvant chemotherapy
- Primary outcome
- Changes in biomarker levels (myokines and osteokines) and functional physical outcomes
- Effect size
- —
- Significance
- Not reported
- Journal
- Pharos University in Alexandria
- Published
- Sep 8, 2026
Sources
Primary source
- Pharos University in Alexandria ↗Clinical trial
Source versions
Assessment history
9/23/2026 · SUPERSEDED: Source updated; assessment withdrawn pending review.
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