Registry update — unassessed
Clinical Evaluation of mTORC1 Inhibition for Geroprotection
Trial registry update: COMPLETED. No results reported in the supplied registry record.
RCTRoutine significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 4, 2026 · Discovered: Sep 18, 2026 · Assessed: — · Research update
What it does not prove
- The abstract does not report actual results, outcomes, or whether the intervention was safe or effective—only the study design and planned protocol
- No effect sizes or sample sizes are provided, making it impossible to assess statistical power or the magnitude of any effects
- Comparison to the younger non-treated group does not constitute a control arm for the primary intervention question
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- 38 months
- Population
- Participants aged 55-80 years old who are insulin resistant or prediabetic (intervention group); Participants aged 18-35 (non-intervention control group)
- Primary outcome
- Safe improvement in physiological and molecular hallmarks of aging in humans
- Effect size
- —
- Significance
- Not reported
- Journal
- University of Wisconsin, Madison
- Published
- Sep 4, 2026
Sources
Primary source
- University of Wisconsin, Madison ↗Clinical trial
Recorded source passages
Abstract or registry material supplied for assessment; source version 2. This is not a claim of full-text review.
The objective of this project is to determine if mTORC1 inhibition by 24 weeks of daily (0.5 mg/day) or weekly (5 mg/week) everolimus can safely improve physiological and molecular hallmarks of aging in humans.
Participants who are 55-80 years old and insulin resistant or prediabetic will be randomized to treatment and can expect to be on study for up to approximately 38 weeks.
Participants aged 18-35 will not receive the intervention and can expect to be on study for up to approximately 8 weeks.
Source versions
Assessment history
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