Registry update — unassessed
Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly: Immune, Cognitive, and Functional Consequences ((Substudy E - RAPA cMRI With LGE)
Trial registry update: ACTIVE_NOT_RECRUITING. No results reported in the supplied registry record.
OTHERRoutine significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 23, 2026 · Discovered: Sep 19, 2026 · Assessed: — · Research update
What it does not prove
- The source does not report actual outcomes or findings from the cardiac imaging analysis
- Whether rapamycin affected cardiac structure or function cannot be determined from this material
- Whether any observed changes were clinically meaningful or related to aging cannot be assessed
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Other
- Sample size
- —
- Duration
- —
- Population
- —
- Primary outcome
- Cardiac function
- Effect size
- —
- Significance
- Not reported
- Journal
- The University of Texas Health Science Center at San Antonio
- Published
- Sep 23, 2026
Sources
Primary source
Recorded source passages
Abstract or registry material supplied for assessment; source version 2. This is not a claim of full-text review.
The ability to mount an effective immune response declines with age, leaving the elderly increasingly susceptible to infectious diseases and cancer.
Rapamycin, an FDA approved drug to prevent transplant rejection, increases the lifespan and healthspan of mice and ameliorates age-related declines in immune responsiveness, cancer survival, and cognition in laboratory animals.
Investigators are conducting a translational trial to test whether rapamycin also improves life functions in humans focusing on elderly persons (aged 70-95).
Substudy E will evaluate the Rapamycin and Cardiac Function.
Source versions
Assessment history
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