Registry update — unassessed
Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation &Amp;Amp;Amp;Amp; Metabolic Rate
Trial registry update: RECRUITING. No results reported in the supplied registry record.
RCTMinor significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 18, 2026 · Discovered: Sep 23, 2026 · Assessed: — · Research update
What it does not prove
- This abstract reports only the study protocol and eligibility criteria, not outcomes or findings, so no conclusions about efficacy can be drawn. The study was designed to test NR in healthy volunteers only, not in the diabetic participants, limiting generalizability to people with metabolic disease. Whether any observed changes in fat oxidation or metabolic rate translate to clinically meaningful benefits for fatty liver disease or weight management is not addressed.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- —
- Population
- Healthy volunteers (men aged 18-65, women aged 18-50, BMI ≥25) and adults with MODY2 (maturity-onset diabetes of the young type 2)
- Primary outcome
- Effect of nicotinamide riboside and low-carbohydrate diet on ketosis, fat oxidation, and metabolic rate
- Effect size
- —
- Significance
- Not reported
- Journal
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Published
- Sep 18, 2026
Funding: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Sources
Primary source
Recorded source passages
Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.
Men aged 18 to 65 and women aged 18 to 50 who are healthy volunteers with a body mass index (height to weight ratio) of 25 or more.
Only healthy volunteers will take the NR, for 14 days at a time, during 1 clinic stay. During their other stay, they will take placebos; these are pills that look like the study supplement but contain no NR.
During each clinic stay, all participants will eat a normal American diet. Then they will eat a ketogenic "low-carb" diet for 5 days.
Assessment history
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