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Metformin
Registry update — unassessed

Effects of Metformin on Longevity Gene Expression and Inflammation and Prediabetic Individuals. A Placebo-controlled Trial

Trial registry update: COMPLETED. No results reported in the supplied registry record.

RCTMinor significance
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Reporter brief

What this changes

The finding has not established an approved change to our evidence assessment.

Source date: Mar 13, 2013 · Discovered: Sep 15, 2026 · Assessed: — · Historical research backfill

What it does not prove

  • This is a protocol abstract with no outcome data reported, so no effects can be established
  • Gene expression changes in blood cells do not establish clinical benefits or effects on actual aging or lifespan
  • The study does not report sample size, effect sizes, or statistical significance for any measured outcomes

Extracted from supplied source material; model confidence is not a measured probability of correctness.

Study details

Design
Rct
Sample size
—
Duration
2 months
Population
Pre-diabetic individuals
Primary outcome
Expression of longevity genes SIRT1, p66Shc, p53 and mTOR in peripheral blood mononuclear cells (PBMCs)
Effect size
—
Significance
Not reported
Journal
University of Padova
Published
Mar 13, 2013

Sources

Primary source

Recorded source passages

Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.

This clinical trial aims to describe the effects of the AMPK pathway on longevity genes and inflammation in the setting of pre-diabetes in vivo and in vitro.
To this end, the investigators will compare treatment with metformin (500 mg t.i.d) for 2 months, versus placebo in pre-diabetic subjects.
The investigators will assess expression of longevity genes SIRT1, p66Shc, p53 and mTOR in peripheral blood mononuclear cells (PBMCs) ex vivo.

Source versions

Version 1: Unassessed

Version 1: Superseded

Assessment history

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