Assessment superseded
Effects of Resistance Exercise Among TGD Individuals Initiating Estrogen-Based Gender-Affirming Hormone Therapy
Trial registry update: RECRUITING. No results reported in the supplied registry record.
RCTMinor significance
What this changes
The finding has not established an approved change to our evidence assessment.
Source date: Sep 11, 2026 · Discovered: Sep 17, 2026 · Assessed: — · Research update
What it does not prove
- The abstract reports the study design and planned outcomes but does not report any findings, effect sizes, or results, making it impossible to assess what the intervention actually achieved.
- As a pilot trial with unspecified sample size, any results would lack statistical power and generalizability beyond the tested population.
- The study compares exercise to counseling-only control rather than to placebo or standard care, so benefits cannot be isolated from attention or expectancy effects.
Extracted from supplied source material; model confidence is not a measured probability of correctness.
Study details
- Design
- Rct
- Sample size
- —
- Duration
- 3 months
- Population
- Transgender women and gender-diverse individuals about to be initiated or recently initiated (≤3 months ago) on estrogen-dominant gender-affirming hormone therapy
- Primary outcome
- Effects on muscle mass, strength, and function in transgender and gender-diverse individuals initiating estrogen-based gender-affirming hormone therapy
- Effect size
- —
- Significance
- Not reported
- Journal
- Massachusetts General Hospital
- Published
- Sep 11, 2026
Sources
Primary source
- Massachusetts General Hospital ↗Clinical trial
Recorded source passages
Abstract or registry material supplied for assessment; source version 1. This is not a claim of full-text review.
Estrogen-dominant gender-affirming hormone therapy (GAHT) is standard of care for transgender women and gender-diverse individuals
As part of NCT04128488, our investigative team found that appendicular lean mass (ALM)/ height2 decreases after estrogen-based GAHT
For this prospective, pilot clinical trial, investigators will enroll participants who are about to be initiated or recently initiated (3 months ago or less) on estrogen-dominant gender-affirming hormone therapy
Investigators will be randomizing participants 1:1 to either an at-home resistance exercise intervention or no exercise intervention (nutritional and exercise counseling only) for 12 weeks
The exercise intervention group will be provided with the necessary materials to complete the exercise program along with weekly virtual visits
Source versions
Assessment history
9/24/2026 · SUPERSEDED: Source updated; assessment withdrawn pending review.
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