Resistance training

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Trial registry update: RECRUITING. No results reported in the supplied registry record.

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Trial registry update: RECRUITING. No results reported in the supplied registry record.

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Trial registry update: COMPLETED. No results reported in the supplied registry record.

Trial registry update: COMPLETED. No results reported in the supplied registry record.

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Trial registry update: RECRUITING. No results reported in the supplied registry record.

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Trial registry update: COMPLETED. No results reported in the supplied registry record.

Trial registry update: COMPLETED. No results reported in the supplied registry record.

Trial registry update: COMPLETED. No results reported in the supplied registry record.

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Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.

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Trial registry update: RECRUITING. No results reported in the supplied registry record.

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Trial registry update: COMPLETED. No results reported in the supplied registry record.

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Trial registry update: COMPLETED. No results reported in the supplied registry record.

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Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.

Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.

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Trial registry update: RECRUITING. No results reported in the supplied registry record.

Trial registry update: COMPLETED. No results reported in the supplied registry record.

Trial registry update: COMPLETED. No results reported in the supplied registry record.

Trial registry update: NOT_YET_RECRUITING. No results reported in the supplied registry record.

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Trial registry update: COMPLETED. Results are posted in the registry; assessment pending.

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This systematic review examined molecular mechanisms of skeletal muscle aging, emphasizing that age-related muscle dysfunction results from more than just mass loss, involving changes across myofibers, stem cells, immune, vascular, and metabolic systems. The authors reviewed therapeutic evidence and identified exercise and nutritional optimization as established clinical approaches, while mitochondrial, anabolic, senescence-directed, and regenerative strategies are presented as emerging interventions. The review synthesized evidence from single-cell, multi-omics, and translational studies to propose a framework of muscle aging centered on impaired proteostasis, mitochondrial dysfunction, chronic inflammation, and cellular senescence.

This was a randomized controlled trial comparing 8 weeks of lower-limb rehabilitation robot training plus nutrition education versus usual care (exercise and nutrition education) in adults aged 60+ with sarcopenia. The study measured muscle mass, body composition, strength, walking ability, balance, and quality of life at baseline, week 5, and week 8. The abstract does not report the results, sample size, or effect sizes.

This randomized controlled trial compared a 12-week home-based multicomponent exercise program delivered via a Telegram chatbot versus paper-based instructions in community-dwelling older adults. Both groups performed identical exercises targeting strength, balance, flexibility, and walking. The primary outcome was exercise adherence; secondary outcomes included physical function, physical activity, satisfaction, and safety. No results on outcomes were reported in the provided abstract.

In this 12-week randomized trial of 79 community-dwelling older adults with cognitive frailty, participants assigned to exergaming combined with elastic band resistance training (3 sessions/week, 50 min each) showed significantly greater improvements in physical activity (IPAQ-SF +586.1 MET-min/week, 95% CI 454.5–717.7) and exercise self-efficacy (SEE +3.3, 95% CI 2.4–4.2) compared to routine health education alone. The intervention group achieved 86.5% adherence, and qualitative interviews (n=13) identified themes of enhanced enjoyment, positive health perceptions, and improved social interaction.

This randomized controlled trial compared acute neuromuscular and physiological responses to power training on a pneumatic leg press at three different velocity loss thresholds (fatigue levels) in healthy adults aged 65–85 years. Participants completed three supervised sessions approximately one week apart, with measurements of strength, mobility, blood markers, perceived exertion, and muscle soreness taken before and after exercise.

This is a planned RCT that aimed to recruit 16 healthy men over 50 years old to investigate how rapamycin (a mTOR inhibitor) affects muscle mass and function, both as monotherapy and combined with resistance exercise training. The source provided only the study rationale and design intent, with no outcome data reported.

This randomized controlled trial enrolled postmenopausal women aged 60-75 years in a 1:1:1:1 design comparing oral everolimus 5 mg weekly, placebo weekly, everolimus plus resistance training (3 hours weekly), or placebo plus resistance training. The study measured bone formation, muscle function, bone and muscle protein turnover, and quality of life through imaging, biopsies, blood samples, and functional testing across 5-7 visits. No results are reported in the material provided.

A meta-analysis of 14 randomized controlled trials (n=893, ages 30-94) examined the effect of exercise training on circulating α-Klotho. Chronic training (≥12 weeks) produced a pooled effect of Hedges' g=1.20 (95% CI 0.85-1.55). In chronic kidney disease patients specifically, exercise increased Klotho by 158.82 pg/mL and reduced FGF23 by 102.07 pg/mL. Resistance training and high-intensity interval training showed the most robust effects.

This is a study protocol (not yet reporting results) examining whether a 6-week supervised resistance training intervention improves mitochondrial function and physical performance in approximately 120 participants: older adults with type 2 diabetes, healthy older adults, and young healthy controls. The study will measure changes in muscle strength, frailty, body composition, and detailed cellular assessments including mitochondrial function, muscle fiber morphology, gene expression, and gut microbiota.

This is a randomized feasibility trial protocol examining whether supervised aerobic and strength exercise is practical and safe during neoadjuvant chemotherapy for breast cancer. Participants were assigned to supervised exercise or usual care, with comparisons made before and after chemotherapy. The protocol does not report sample size, effect sizes, or actual results from the trial.

This is a registered clinical trial protocol that planned to examine how age affects skeletal muscle mitochondrial function and whether a 4-week home-based exercise intervention could alter this. The study compared high-intensity interval training (HIIT) to resistance training using bands in older participants.

This randomized controlled trial enrolled hospitalized adults aged 60+ to test whether adding virtual reality exercise (VRAGMENT program) to conventional multimodal exercise would improve lactate kinetics, functional status, frailty, sarcopenia risk, perceived exertion, and quality of life. The study measured lactate concentrations before and after low-intensity resistance exercise on Days 1 and 7, and assessed functional independence, frailty, sarcopenia risk, and quality of life at baseline and Day 7. No results, effect sizes, or sample size were reported in the provided material.

This is a protocol for an intervention study within extension projects at UFBA evaluating multicomponent training and gymnastics in adults and older adults (60+). The planned study will measure anthropometric, sociodemographic, and physical-functional outcomes, along with quality of life, sleep quality, fear of falling, and activities of daily living before and after intervention. No results are reported.

This randomized controlled trial evaluated a 6-week supervised pool-based exercise program in adults aged 65 and older with sarcopenia, identified by ultrasound thigh muscle thickness. The study measured muscle strength, muscle morphology, physical performance, mood, and quality of life at baseline, immediately post-intervention, and at 1-month follow-up.

This randomized controlled trial compared four arms—minimalist footwear, a foot exercise program, a foot-strengthening device (ToePro), and no intervention—in middle-aged and older adults (ages 45-85) over 8 weeks. Participants completed foot strength, balance, gait, and physical function testing at baseline and post-intervention, with interventions performed five days per week. The abstract does not report specific effect sizes, statistical outcomes, or whether any intervention produced meaningful changes.

PhActHealth is a multicenter RCT enrolling women with newly diagnosed luminal B or triple-negative breast cancer. Participants were randomly assigned to lifestyle counseling alone (control) or counseling plus a personalized aerobic and resistance exercise program during neoadjuvant treatment. The study measured exercise capacity as the primary outcome, with secondary outcomes including immune response, autonomic nervous system regulation, cardiovascular health, and tumor aggressiveness markers.

This pilot randomized controlled trial tested combined inspiratory muscle training and blood flow restriction in frail older adults. The study assessed feasibility and preliminary effects on physical function, respiratory strength, handgrip, sit-to-stand performance, body composition, frailty, fall efficacy, and blood pressure. Specific findings on efficacy outcomes were not reported in the abstract provided.

This pilot study investigated whether older adults could achieve adequate muscle activation at a point of perceived moderate discomfort rather than training to technical failure during bodyweight exercises (squats and push-ups). Researchers measured electromyography (EMG) activation in the quadriceps and triceps and counted repetitions between the point of moderate discomfort and failure. The motivation was to identify whether stopping at discomfort rather than failure could provide training benefits while improving adherence in older populations.

The ACTIONcardioRisk trial investigated the effect of combined aerobic exercise, progressive resistance training, and cognitive training on neurocognitive functioning in sedentary older adults with and without cardiovascular risk factors. The abstract does not report what effects were found, sample size, or effect sizes.

This 8-week study examined a combined land and aquatic exercise program conducted 3 days per week in older adults. Physical performance was measured using handgrip strength and the 30-second chair sit-up test, while recreational swimming behaviors and water-related risk perceptions were assessed through questionnaires. The abstract provides no reported results, effect sizes, or sample size details.

A randomized controlled pilot feasibility trial examined whether polyphenol supplementation combined with 12 weeks of supervised resistance and aerobic exercise could improve physical function and muscle health in older adults compared to placebo. Participants received either a polyphenol blend or maltodextrin placebo while completing the exercise program. The study included exploratory analysis of muscle biopsies and plasma samples to assess cellular and molecular effects.

This randomized clinical trial tested a home-based multicomponent exercise program (strength, balance, flexibility, mobility training) with periodic monitoring and three-weekly progression in centenarians from the BIOANCIENT cohort. The abstract does not report the sample size, primary outcomes measured, or any effect sizes or results.

This randomized clinical trial tested a home-based multicomponent exercise program (Vivifrail) in community-dwelling adults aged 90 and older. Participants were assigned to Vivifrail twice weekly, Vivifrail three times weekly, or control, with physical function measured by Short Physical Performance Battery at baseline, 12 weeks, and 24 weeks.

A pilot mixed-methods RCT evaluated 14 weeks of elastic band-based progressive resistance training in heart failure patients with sarcopenia. The study measured muscle mass, strength, physical performance, heart failure severity markers, and health-related quality of life, followed by qualitative interviews about engagement. Specific effect sizes and sample size details were not reported in this abstract.

This randomized controlled trial compared a 3-month progressive exercise program (aerobic and resistance training) plus standard care versus standard chemotherapy and nutritional counseling alone in patients aged 40-60 receiving neoadjuvant chemotherapy for non-metastatic cancer. The study measured biomarkers related to muscle-bone signaling (myokines and osteokines) and functional physical outcomes to assess whether targeted exercise could attenuate cachexia.

This is a randomized controlled trial comparing home-based aerobic exercise (AE), combined aerobic and resistance exercise (ARE), and control (physical activity counseling) in adult patients with chronic liver disease who have complications including sarcopenia, malnutrition, and fatigue. The 8-week intervention measured oxygen consumption, muscle strength, body composition, frailty, fatigue, and quality of life before and after the program. The abstract describes the study design and planned measurements but does not report the actual results or findings.

This pilot randomized controlled trial examined whether preoperative prehabilitation combining neuromuscular strength training and sedentary behavior reduction would reduce surgical complications, length of stay, and improve recovery in patients undergoing elective surgery. The authors note that exercise can modify molecular drivers of frailty and that reducing sedentary behavior is recommended to prevent frailty, but the abstract does not report the study's actual findings on these outcomes.

A double-blinded RCT compared a digital therapeutic device (exoDTx) to self-exercise in patients with sarcopenia. The study aimed to demonstrate superiority of the device for improving muscle strength and safety, though specific effect sizes and sample size are not reported in the available material.

A randomized controlled trial tested a community-based physical exercise program in people aged 50 and older with multiple chronic diseases including cardiovascular disease, diabetes, or musculoskeletal disease. The program aimed to improve cardiorespiratory fitness, muscular strength, bone health, functional capacity, and quality of life through personalized exercise prescription. The abstract describes the study design and objectives but does not report the actual findings, effect sizes, or whether outcomes improved.

This prospective pilot RCT randomized participants initiating or recently initiated on estrogen-dominant gender-affirming hormone therapy 1:1 to a 12-week at-home resistance exercise intervention or control (nutritional and exercise counseling only). Muscle mass, strength, and function were assessed before and after the intervention period, with survey measures of gender congruence also collected.

This study evaluated the acceptability, feasibility, and safety of a prehabilitation program (combining exercise and nutrition) designed for head and neck cancer patients before surgery. The authors examined whether such a program could be safely implemented in this population, but the abstract does not report specific outcome data or sample characteristics.

This six-week, sham-controlled randomized trial compared twice-weekly low-load cycling with individualized blood flow restriction (BFR) versus sham BFR in community-dwelling adults over 70. The intervention group received cycling with thigh cuffs calibrated to each participant's limb occlusion pressure, while controls received identical cycling with fixed low sham cuff pressure. The study measured functional mobility (DEMMI), quality of life (SF-36), and secondary outcomes including strength, walking capacity, and safety parameters.

The SARCO-COX trial randomized 150 adults aged 65+ with advanced hip osteoarthritis into three groups: sarcopenic patients receiving structured postoperative exercise, sarcopenic patients receiving standard care, and non-sarcopenic patients receiving standard care. The study assessed whether early sarcopenia screening followed by targeted exercise improves muscle strength, mass, physical function, pain, and quality of life compared to usual care.

This randomized controlled trial compared exercise snacks (short bouts throughout the day), home-based resistance training, and a non-exercise control group in older adults with possible sarcopenia over 8 weeks. Muscle strength and physical function were assessed before and after the intervention. Results were not reported in the provided abstract.

A randomized controlled trial assigned hemodialysis patients to one of three groups: aerobic exercise using a cycle ergometer, resistance exercise using elastic bands, or standard care. After 6 months, researchers assessed physical function, body composition, quality of life, and dialysis-related outcomes. The abstract does not report the actual results, sample size, or effect sizes.

A 16-week randomized controlled trial assigned older adults (≥60 years) with low physical activity and excess body fat to one of three groups: resistance training alone, resistance training plus weekly cognitive behavioral therapy, or resistance training plus cognitive behavioral therapy plus weekly nutritional guidance for higher protein intake. The study aimed to assess changes in body composition, muscle strength and function, metabolic and vascular health, cognitive function, and psychological outcomes, with results to be compared across the three groups to determine whether adding behavioral and nutritional components to resistance training provided additional benefits.

This study protocol describes an 8-week forest-based intervention combining exercise (trail walking, resistance training, stretching) with sensory activities (aromatherapy, deep breathing) delivered twice weekly in 180-minute sessions at a forest healing facility. The study aims to measure effects on muscle strength, physical performance, and psychological well-being in older women with sarcopenia, with assessments at baseline, post-intervention, and 1-month follow-up. No results are reported.

This RCT assigned 30 healthy men aged 60-75 to four weeks of moderate-intensity resistance training or control. The study measured diaphragm thickness via CT scan as the primary outcome, with secondary measures of hepatic fat density and quality of life via SF-12. The abstract does not report the actual findings for any outcome.

This RCT evaluated a computational ecosystem called MOTIVA that combines resistance training (VIVIFRAIL program) with motivational support and functional assessment for unsupervised exercise in community-dwelling older adults. The study aimed to determine whether this system would improve independence, physical and cognitive health, and reduce healthcare utilization in robust and prefrail participants. The abstract does not report the sample size, effect sizes, or specific results obtained.

This RCT examined whether metformin enhances the adaptations to resistance exercise in older adults. The study aimed to determine whether metformin could increase muscle mass and strength gains during resistance training. No sample size, effect size, or specific results are reported in the provided material.

A randomized controlled trial of 80 prefrail and frail men aged ≥60 undergoing radical prostatectomy compared short-term home-based multimodal prehabilitation (exercise, nutrition, psychology, pelvic floor training, breathing, health guidance) to usual care alone over a median 12-day preoperative period. The prehabilitation group improved 6-minute walk distance by 27.70 m from baseline to preoperatively, while usual care declined by 3.12 m, yielding a 30.82 m between-group difference (P < 0.001). Exploratory findings suggested faster early ambulation, gastrointestinal recovery, and shorter hospital stay.